A Mannsdale Road residence was destroyed by fire over weekend while the homeowners were away.

Chief Henry Davis with the South Madison Fire District said that they received a call reporting a fire around 5:30 p.m. The Gluckstadt Fire Department responded immediately. Davis said that Flora and Madison Fire Departments responded as well, offering additional manpower and water.

Efforts to fight the fire blocked all lanes of traffic on MS Highway 463 between Livingston Drive and Stripling Road. Davis said he had crews fighting the fire for about seven hours.

No injuries were reported. The homeowners were not home at the time the blaze started, Davis said.

Davis said the fire started in the garage, where it then spread to the attic.

“The house is pretty much a total loss. Once a fire like this gets into the attic it is very difficult to get ahead of it,” Davis said.

Davis said an investigation being conducted by the state Fire Marshall's Office and his department is ongoing as to the cause.